Synthesis, Characterization & Biological Activity Assessment of a New Oxadiazole Derivative Based on Nicotinic Hydrazide and Using It for Extraction of Ni and Co from Aqueous Solutions
DOI:
https://doi.org/10.31185/wjps.671Abstract
In a recent study, a novel chemical generated from 1,3,4-oxadiazole was synthesized by mixing transition metals with nicotinic hydrazide using their water-dissolved chloride salts. To determine the chemical properties of the bonds and their chains, H1-NMR, FT-IR, and mass spectrometry(MS) methods were used. In addition, conduction sensitivity measurements were performed. The size of the inhibitory zone for Candida Kruse, Candida albicans, Pseudomonas aeruginosa, and Staphylococcus aureus, was assessed after generated complexe was tested against bacteria by means of the diffusion method. The Hyper Chem program was used to do theoretical calculations utilizing the MP3 approach in order to examine the stability energy of compounds and pinpoint the precise sites where they form complexes with metal elements.
References
Ciccolini, C. (2020). Synthesis of Mono and Poly-Heterocycles starting from 1, 2-Diaza-1, 3-Dienes (or precursors) as Building Blocks.
Benassi, A., Doria, F., & Pirota, V. (2020). Groundbreaking anticancer activity of highly diversified oxadiazole scaffolds. International journal of molecular sciences, 21(22), 8692.
Palit, R., Nikita, S., & Sahoo, J. (2016). Review on substituted 1, 3, 4-oxadiazole and its biological activities. The International Research Journal of Pharmacy, 7(2), 1-7.
Wang, M. W., Zhu, H. H., Wang, P. Y., Zeng, D., Wu, Y. Y., Liu, L. W., ... & Yang, S. (2019). Synthesis of thiazolium-labeled 1, 3, 4-oxadiazole thioethers as prospective antimicrobials: In vitro and in vivo bioactivity and mechanism of action. Journal of agricultural and food chemistry, 67(46), 12696-12708.
Zoufalý, P., Kliuikov, A., Čižmár, E., Císařová, I., & Herchel, R. (2021). Cis and Trans Isomers of Fe (II) and Co (II) Complexes with Oxadiazole Derivatives‐Structural and Magnetic Properties. European Journal of Inorganic Chemistry, 2021(12), 1190-1199.
Cignitti, M., & Paoloni, L. (1967). The electronic structure of groups of isomeric hetero-aromatic systems: I. Derivatives of 1, 2, 4-oxadiazole. Theoretica chimica acta, 7, 383-401.
Zhu, L., Zeng, H., Liu, D., Fu, Y., Wu, Q., Song, B., & Gan, X. (2020). Design, synthesis, and biological activity of novel 1, 2, 4-oxadiazole derivatives. BMC chemistry, 14, 1-12.
Glomb, T., & Świątek, P. (2021). Antimicrobial activity of 1, 3, 4-oxadiazole derivatives. International journal of molecular sciences, 22(13), 6979.
Kulkarni, S., Kaur, K., & Jaitak, V. (2022). Recent developments in oxazole derivatives as anticancer agents: Review on synthetic strategies, mechanism of action and SAR studies. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 22(10), 1859-1882.
Bala, M., Piplani, P., Ankalgi, A., Jain, A., & Chandel, L. (2023). 1, 3, 4-Thiadiazole: A versatile pharmacophore of medicinal significance. Medicinal Chemistry, 19(8), 730-756.
Rajalekshmi, R., & Agrawal, D. K. (2024). Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases. International Journal of Plant, Animal and Environmental Sciences, 14(4), 104-129.
Heeres, J., Meerpoel, L., & Lewi, P. (2010). Conazoles. Molecules, 15(6), 4129-4188.
Yadav, D., Kumar, S., Kumar, A., & Kumar, V. (2024). Azole-based organometallic compounds as bioactive agents. In Recent Advances in Organometallic Chemistry (pp. 287-307). Elsevier.
Ungureanu, D., Oniga, O., Moldovan, C., Ionuț, I., Marc, G., Stana, A., ... & Tiperciuc, B. (2024). An Insight into Rational Drug Design: The Development of In-House Azole Compounds with Antimicrobial Activity. Antibiotics, 13(8), 763.
Patel, S. A. (2024). 1, 3, 4-Oxadiazole: Synthesis and Pharmacological Applications. Crown Publishing.
Durmaz, Ş., Evren, A. E., Sağlık, B. N., Yurttaş, L., & Tay, N. F. (2022). Synthesis, anticholinesterase activity, molecular docking, and molecular dynamic simulation studies of 1, 3, 4‐oxadiazole derivatives. Archiv der Pharmazie, 355(11), 2200294.
Shablykin, O. V., Brovarets, V. S., & Shablykina, O. V. (2024). Recyclization of 5‐Amino‐oxazoles as a Route to new Functionalized Heterocycles (Developments of VP Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine). The Chemical Record, 24(2), e202300264.
Arshad, M. F., Alam, A., Alshammari, A. A., Alhazza, M. B., Alzimam, I. M., Alam, M. A., ... & Jomah, S. (2022). Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents. Molecules, 27(13), 3994.
Schnaar, R. L., & Needham, L. K. (1994). [23] Thin-layer chromatography of glycosphingolipids. In Methods in enzymology (Vol. 230, pp. 371-389). Academic Press.
Das, D., Kannan, S., Kumar, M., Sadhu, B., & Kumbhare, L. B. (2022). Synthesis, photophysical properties and catalytic activity of Ƙ3-SCS pincer palladium (II) complex of N, N'-di-tert-butylbenzene-1, 3-dicarbothioamide supported by DFT analysis. Inorganica Chimica Acta, 531, 120704.
Daud, S., Saadullah, M., Fakhar-e-Alam, M., Carradori, S., Sardar, A., Niaz, B., ... & Rashad, M. (2024). Isatin-based ibuprofen and mefenamic acid Schiff base derivatives as dual inhibitors against urease and α–glucosidase: in vitro, in silico and cytotoxicity studies. Journal of Saudi Chemical Society, 28(5), 101905.
Chakraborty, M., & Bhattacharyya, A. (2008). "Extraction of Cobalt and Nickel from Aqueous Solutions Using Bis(oxadiazole) Derivatives." Journal of Chemical Engineering and Technology, 31(2), 212-219.
This paper discusses the use of oxadiazole derivatives for the extraction of cobalt and nickel from aqueous solutions and provides detailed information on the extraction conditions, efficiency, and the mechanism of extraction.
Sundararajan, M., & Sharma, S. R. (2001). "Solvent Extraction of Nickel and Cobalt Using 2,5-Dimethyl-1,3,4-Oxadiazole Derivatives." Separation Science and Technology, 36(7), 1677-1686.
This study focuses on the solvent extraction of nickel and cobalt using various oxadiazole derivatives and explores the influence of different solvents, pH, and ligand concentrations on extraction efficiency.
Srinivasan, T., & Ghosh, A. K. (2006). "Extraction of Cobalt and Nickel from Acidic Solutions Using Oxadiazole Derivatives: Kinetics and Thermodynamics." Hydrometallurgy, 84(3–4), 168-176.
This paper provides a detailed analysis of the kinetics and thermodynamics of the extraction of cobalt and nickel using oxadiazole derivatives, including the role of temperature, pH, and solvent properties.
Margarita, P., & Sassi, M. A. (2013). "Solvent Extraction of Nickel and Cobalt from Sulfate Solutions Using Oxadiazole-based Ligands." Separation and Purification Technology, 111, 58-65.
This paper investigates the extraction of nickel and cobalt from sulfate solutions using oxadiazole-based ligands and compares the extraction performance with other chelating agents.
Mishra, A. K., & Shukla, A. (2002). "Studies on the Extraction of Nickel and Cobalt by Oxadiazole Derivatives." Journal of Applied Chemistry, 52(6), 876-882.
Hassan, W. M., & Mahgoub, M. E. (2011). "Synthesis, Characterization, and Biological Activities of Some Metal Complexes of Oxadiazole Derivatives." Journal of Coordination Chemistry, 64(9), 1409–1418.
El-Bindary, A. A., & El-Sherif, S. A. (2008). "Synthesis, Spectral Characterization, and Antibacterial Activity of Some Transition Metal Complexes with Oxadiazole Derivatives." Journal of Inorganic Biochemistry, 102(8), 1371–1377.
MEHANDI, Rabiya, et al. Oxadiazole Schiff Base as Fe3+ Ion Chemosensor:“Turn-off” Fluorescent, Biological and Computational Studies. Journal of Fluorescence, 2023, 33.2: 751-772.
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