Association of renalase genotypes with their serum levels in Iraqi hypertensive patients

Abstract

Due to its worldwide prevalence, hypertension poses a significant threat to public
health. Renalase helps regulate blood pressure and heart function by breaking down catecholamines in the bloodstream. As its effects are linked to alterations in multiple organs.
This study aims to investigate the association of polymorphism of renalase gene rs
(2296545) to their serum levels among Iraqi hypertensive patients A total of 70 volunteers
(50 verified hypertension patients and 20 healthy individuals who served as controls) were
selected using a practical selection technique. Genetic polymorphism of the renalase gene
(rs2296545) was carried out using RFLP-PCR. Serum levels of renalase were performed
using the enzyme-linked immunosorbent assay technique (ELISA) using a Human- renalase
kit . This study demonstrates that renalase serum levels were markedly higher in hypertensive patients although there was an insignificant difference (72.2±12.6), controls
(65.40±8.91), P= 0.071. The results of this study also demonstrate a marked increase in the
levels of renalase among patients with hypertension who have the genotype CC
104.02±9.10 compared to controls43.58±4.04, P> 0.05 while the hypertensive patients with
GG genotype had the lowest level of renalase70.68±22.16 compared to controls 28.233±
0.0, P> 0.05.