Evaluation of some hematological and biochemical parameters for women with polycystic ovary syndrome in Wasit Governorate

Authors

  • meaad khudhair College of Education for Pure Sciences, University of Wasit

DOI:

https://doi.org/10.31185/wjps.259

Keywords:

polycystic ovary syndrome , hematological , biochemical parameters

Abstract

The aim of the study; the Study of physiological causes and risk factors of ovarian cysts in women and Analyzing the results statistically to determine the extent of the relationship between the physiological and biochemical causes of the occurrence of polycysticovaries. Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting many females in reproductive period which start from menarche till the menopause and commonly caused infertility around the world, and is characterized by irregular menstrual cycle, Hyperandrogensim and polycystic ovary; it can be considered a conditions involving reproductive, metabolic and cardiovascular components leading to lifelong health implication. Its prevalence among infertile women is between (15% to 20%). There is evidence that PCOS is a pro inflammatory disorder, characterized by the presence of low grade chronic inflammation that correlated with obesity or insulin resistance (IR). The purpose of this study is to investigate the role of study included 100 females diagnosed with PCOS, there were recruited from Al-kut hospital in Wasit during November 2022 until January 2023 , the diagnosis of polycystic ovary syndrome was based on the Rotterdam 2003 criteria. The control group consists of 50 fertile women who have regular menstrual cycle with no sign of hyperandrogenism and subjected to ultrasound examination and have normal hormonal levels. The age was identical in both groups and it was between (20-40) years. . Body mass index (BMI) for both patients and control group was calculated. The questionnaire form has been filled for each patient and control. Hormones levels luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) were estimated. The present study was carried out in two parts: immunological and physiological study. ELISA technique has been used to determine the serum level of High –sensitivity C-reactive protin(Hscrp) . The results of Hscrp serum level was significantly increased (p<0.oo5) in pcos patient(17.38+1.36) The results for physiological study demonstrated that insulin serum level recorded a highly significant difference (p <0.05) in PCOS patients compared to control group, the mean level of this hormone for PCOS patients and control were (17.18±2.84) μIU/mL, (8.68±1.97) μIU/mL respective. While this study showed there were no significant differences in serum levels of T.protin, and TSH between PCOS patients (8.08± 1,28). ng/mL(, 0.79±0.17)μg/dL, and control group (7.09±0.51) ng/mL,( 1.20±0.09) μg/dL. This study illustrate that the serum levels of Hscrp and insulin were elevated in PCOS comparing to healthy women and this high levels related to PCOS independent on the presence of obesity or IR., and there was a positive correlation between the insulin hormone with the parameters Hscrp and this may be due to the background of PCOS which considered as inflammatory disease The reslts showed that ,Creatin ,cholesterol,GPT, and LDL ,Lympho ,TG were significantly increased in pcos patients than control group

References

Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021). mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nature reviews Drug discovery, 20(11), 817-838.

Deswal, R., Narwal, V., Dang, A., & Pundir, C. S. (2020). The prevalence of polycystic ovary syndrome: a brief systematic review. Journal of human reproductive sciences, 13(4), 261.

Ghatnatti, V., Patil, S., & Kour, H. (2022). Assessment of clinical, biochemical, and hormonal profile of lean versus overweight polycystic ovarian syndrome patients: a cross-sectional study. APIK Journal of Internal Medicine, 10(1), 13-16.

Chouhan, L., Ito, S., Thomas, E. M., Takano, Y., Ghimire, S., Miyasaka, H., & Biju, V. (2021). Real-time blinking suppression of perovskite quantum dots by halide vacancy filling. ACS nano, 15(2), 2831-2838. Qi, Y. X., Han, Y., & Jiang, Z. L. (2018).

Conway, G., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Franks, S., Gambineri, A., ... & Yildiz, B. O. (2014). The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. European journal of endocrinology, 171(4), P1-P29

Villa, J., & Pratley, R. E. (2011). Adipose tissue dysfunction in polycystic ovary syndrome. Current diabetes reports, 11, 179-184.‏

Grapsa, D., Kairi-Vassilatou, E., Kleanthis, C., Dastamani, C., Fillipidou, A., & Kondi-Pafiti, A. (2011). Epithelial ovarian tumors in adolescents: a retrospective pathologic study and a critical review of the literature. Journal of Pediatric and Adolescent Gynecology, 24(6), 386-388.

Vernon, G., Baranova, A., & Younossi, Z. M. (2011). Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults. Alimentary pharmacology & therapeutics, 34(3), 274-285.

Habib, A., & Hasan, M. M. (2017). Social capital and corporate cash holdings. International Review of Economics & Finance, 52, 1-20.‏

Qin, J., Liu, Y., & Grosvenor, R. (2016). A categorical framework of manufacturing for industry 4.0 and beyond. Procedia cirp, 52, 173-178. of Economics & Finance, 52, 1-20.

Zhang, W., Gupta, S., Lian, X., & Liu, J. (2015). Staleness-aware async-sgd for distributed deep learning. arXiv preprint arXiv:1511.05950.

Ellis, S. B., Williams, M. E., Ways, N. R., Brenner, R., Sharp, A. H., Leung, A. T., ... & Harpold, M. M. (1988). Sequence and expression of mRNAs encoding the α1 and α2 subunits of a DHP-sensitive calcium channel. Science, 241(4873), 1661-1664.‏

Patel, S. R., Ayas, N. T., Malhotra, M. R., White, D. P., Schernhammer, E. S., Speizer, F. E., ... & Hu, F. B. (2004). A prospective study of sleep duration and mortality risk in women. Sleep, 27(3), 440-444

Allahbadia, G. N., & Merchant, R. (2011). Polycystic ovary syndrome and impact on health. Middle East Fertility Society Journal, 16(1), 19-37.‏

Joham, A. E., Teede, H. J., Ranasinha, S., Zoungas, S., & Boyle, J. (2015). Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: data from a large community-based cohort study. Journal of women's health, 24(4), 299-307.‏

Al-Musawy, S. H., Al-Saimary, I. E., & Flaifil, M. S. (2018). Levels of cytokines profile in polycystic ovary syndrome. Medical Journal of Babylon, 15(2), 124-128.

Barbieri, L., Battelli, M. G., & Stirpe, F. (1993). Ribosome-inactivating proteins from plants. Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes, 1154(3-4), 237-282.

Lizneva, D., Suturina, L., Walker, W., Brakta, S., Gavrilova-Jordan, L., & Azziz, R. (2016). Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertility and sterility, 106(1), 6-15.

Tsilchorozidou, T., Overton, C., & Conway, G. S. (2004). The pathophysiology of polycystic ovary syndrome. Clinical endocrinology, 60(1), 1-17

Phillips, M. L., Young, A. W., Senior, C., Brammer, M., Andrew, C., Calder, A. J., ... & David, A. S. (1997). A specific neural substrate for perceiving facial expressions of disgust. Nature, 389(6650), 495-498.

Verthelyi, D., Ishii, K. J., Gursel, M., Takeshita, F., & Klinman, D. M. (2001). Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. The Journal of Immunology, 166(4), 2372-2377.

Dinnen, S. (2002). Winners and losers: Politics and disorder in the Solomon Islands 2000-2002. Journal of Pacific History, 37(3), 285-298.‏

Nada, S. Z., & Al-Wazzan, H. A. J. (2021). The role of heat shock protein 70 and dysglycemia in Iraqi Women with Polycystic Ovarian Syndrome. Al-Qadisiyah Medical Journal, 17(2).

Koren, T., Amer, M., Krot, M., Boshnak, N., Ben-Shaanan, T. L., Azulay-Debby, H., ... & Rolls, A. (2021). Insular cortex neurons encode and retrieve specific immune responses. Cell, 184(24), 5902-5915.

Allahbadia, G. N., & Merchant, R. (2011). Polycystic ovary syndrome and impact on health. Middle East Fertility Society Journal, 16(1), 19-37.

Allahbadia, G. N., & Merchant, R. (2011). Polycystic ovary syndrome and impact on health. Middle East Fertility Society Journal, 16(1), 19-37.

Dittrich, H., Stadler, A., Topa, D., Schimper, H. J., & Basch, A. (2009). Progress in sulfosalt research. Physica status solidi (a), 206(5), 1034-1041.‏

Lüthi, M. (2008). Es war einmal: vom Wesen des Volksmärchens. Vandenhoeck & Ruprecht.‏

Mehde, A. A. (2009). Evaluation of Some Biochemical Markers in Patient's Sera of Polycystic Ovarian Syndrome (Doctoral dissertation, University of Baghdad).‏

Huang, Y., Huang, X., Yan, Y., Cai, J., Ouyang, Z., Cui, H., ... & Qin, Q. (2011). Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus. BMC genomics, 12(1), 1-12.‏

AL-Watify, D. G. O. (2014). Abnormalities of hormones and inflammatory cytokines in women affected with polycystic ovary syndrome. Age (years), 27(6.31), 26-4.

shiY, Y. (2013). Santoshm. TectonicevolutionoftheQin lingorogenicbelt, centralchina: Newevidencefrom geo chemical, zirconUrPbgeochronologyandHfisotopes, 231, 19r60

Dale, L., Howes, G. B. M. J. P., Price, B. M. J., & Smith, J. C. (1992). Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. Development, 115(2), 573-585.

Zhang, W., Gupta, S., Lian, X., & Liu, J. (2015). Staleness-aware async-sgd for distributed deep learning. arXiv preprint arXiv:1511.05950.‏

Irvine, P. J., Park, S. S., & Yıldızhan, Ç. (2016). Customer-base concentration, profitability, and the relationship life cycle. The Accounting Review, 91(3), 883-906

Wijeyaratne, C. N., Balen, A. H., Barth, J. H., & Belchetz, P. E. (2002). Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and Caucasians: is there a difference?. Clinical endocrinology, 57(3), 343-350.

Traub, W. A. (2011). Terrestrial, habitable-zone exoplanet frequency from Kepler. The Astrophysical Journal, 745(1), 20.

Corbould, A., Kim, Y. B., Youngren, J. F., Pender, C., Kahn, B. B., Lee, A., & Dunaif, A. (2005). Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. American Journal of Physiology-Endocrinology and Metabolism, 288(5), E1047-E1054

Tagliabue, A., Bopp, L., Dutay, J. C., Bowie, A. R., Chever, F., Jean-Baptiste, P., ... & Jeandel, C. (2010). Hydrothermal contribution to the oceanic dissolved iron inventory. Nature Geoscience, 3(4), 252-256.

AL-Watify, D. G. O. (2014). Abnormalities of hormones and inflammatory cytokines in women affected with polycystic ovary syndrome. Age (years), 27(6.31), 26-4.‏

shiY, YuJH. "Santoshm." TectonicevolutionoftheQin lingorogenicbelt, centralchina: Newevidencefrom geo chemical, zirconUrPbgeochronologyandHfisotopes 231 (2013): 19r60.‏

Selvi, J. Arockia, et al. "Corrosion inhibition by beet root extract." Portugaliae Electrochimica Acta 27.1 (2009): 1-11.‏

Downloads

Published

2023-12-30

Issue

Vol. 2 No. 4 (2023)

Section

Biology

License

Copyright (c) 2023 meaad khudhair

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

khudhair, meaad. (2023). Evaluation of some hematological and biochemical parameters for women with polycystic ovary syndrome in Wasit Governorate. Wasit Journal for Pure Sciences , 2(4), 185-193. https://doi.org/10.31185/wjps.259