Some Molecular Abnormality Indicators of Prenatal Cell Free Fetus DNA CFF-DNA

Abstract

The discovery of CFF-DNA originating from the fetus in the plasma of pregnant women has facilitated the development of noninvasive prenatal testing (NIPT) that compensate for  surgical tests that are expensive and expose mother and her fetus to danger beside it  enable the detection  of  fetal abnormalities and malformation , especially in  pregnant women suffer from problems  such as  preeclampsia , hypertension, gestational diabetes , and other disorders that increase the chance of having children with defects or problems in fetal differentiation. In this  research quantitative real time PCR technology had been used to determine the amplicon's  copy number variations, of  GATA1 and  MDM2 genes between normal and pregnant suffer problem groups  that had an important role in the embryonic   development and differentiation.