Automatic Diagnosis of Ovarian Cancer Based on Relative Entropy and Neural Network

Authors

  • Zainab Harbi Kufa university

DOI:

https://doi.org/10.31185/wjps.172

Abstract

Ovarian Cancer is one of the most common causes of death for women in developing countries. Screening and early diagnoses of OC are urgently needed. Early diagnosis would help in consequence procedures and treatment. Mass spectrometry (MS) data is been used as an effective component of cancer diagnosis tools. However, these valuable data have a large number of dimensions that can affect the learning process in addition to time-consuming considerations. Feature selection plays an important role in reducing information redundancy, and deals with the invalidation that occurs in basic classification algorithms when there are too many features and huge datasets. To improve the automatic system diagnosis accuracy, entropy-based selection features are proposed. These features are combined with the novel learning capabilities of neural networks to achieve higher diagnostic accuracy. Experiments have been performed using different feature selection algorithms and machine learning classification approaches. Experimental results have proved that the proposed system performs better based on the measure of accuracy.

References

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 coun-tries. CA: a cancer journal for clinicians, 71(3), 209-249.

Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022). Cancer sta-tistics, 2022. CA: a cancer journal for clinicians, 72(1), 7-33. ‏

Menon, U., Gentry-Maharaj, A., Burnell, M., Singh, N., Ryan, A., Karpinskyj, C., & Parmar, M. (2021). Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. The Lancet, 397(10290), 2182-2193. ‏

Badgwell D, Bast RC Jr. Early detection of ovarian cancer. Dis Markers. 2007;23(5-6):397-410. doi: 10.1155/2007/309382. PMID: 18057523; PMCID: PMC3851959.

Hossain, K. R., Escobar Bermeo, J. D., Warton, K., & Valenzuela, S. M. (2022). New approaches and biomarker candidates for the early detection of ovarian cancer. Frontiers in Bioengineering and Biotechnology, 10, 157. ‏

Sebastian, A. M., & Peter, D. (2022). Artificial Intelligence in Cancer Re-search: Trends, Challenges and Future Directions. Life, 12(12), 1991. ‏

Wu, B., Abbott, T., Fishman, D., McMurray, W., Mor, G., Stone, K., Zhao, H. (2003). Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data. Bioinformatics, 19(13), 1636-1643. ‏

Vervier, K., Mahé, P., Veyrieras, J. B., & Vert, J. P. (2015). Benchmark of structured machine learning methods for microbial identification from mass-spectrometry data. arXiv preprint arXiv:1506.07251. ‏

Hilario, M., & Kalousis, A. (2008). Approaches to dimensionality reduction in proteomic biomarker studies. Briefings in bioinformatics, 9(2), 102-118. ‏

Emanuel F Petricoin, Ali M Ardekani, Peter J Levine Ben A Hitt, Vincent A Fusaro, Seth M Steinberg, Gordon B Mills, Charles Simone, David A Fishman, Elise C Kohn, and Lance A Liotta. Use of proteomic patterns in serum to identify ovarian cancer. Lancet, 359(9306):572– 577, 2002.

Lihua Li, Hong Tang, Zuobao Wu, Jianli Gong, Michael Gruidl, Jun Zou, Melvyn Tockman, and Robert A Clark. Data mining techniques for cancer detection using serum proteomic profiling. Artif Intell Med, 32(2):71–83, 2004.

Marina Vannucci, Naijun Sha, and Philip J. Brown. Nir and mass spectra classification: Bayesian methods for wavelet-based feature selection. Chemometrics and Intelligent Laboratory Systems, 77(1):139–148, 2005

Wu, J., Ji, Y., Zhao, L., Ji, M., Ye, Z., & Li, S. (2016). A mass spectro-metric analysis method based on ppca and svm for early detection of ovarian cancer. Computational and mathematical methods in medicine, 2016.

Jović, A., Brkić, K., & Bogunović, N. (2015, May). A review of feature se-lection methods with applications. In 2015 38th international convention on information and communication technology, electronics and microelectronics (MIPRO) (pp. 1200-1205). Ieee. ‏

Cover, T. M., & Thomas, J. A. (1991). Entropy, relative entropy and mutu-al information. Elements of information theory, 2(1), 12-13. ‏

Agrawal, S., & Agrawal, J. (2015). Neural network techniques for cancer prediction: A survey. Procedia Computer Science, 60, 769-774. ‏

https://home.ccr.cancer.gov/ncifdaproteomics/ppatterns.asp, Clinical Prote-omics Data Bank, 2014

Conrads, T. P., Fusaro, V. A., Ross, S., Johann, D., Rajapakse, V., Hitt, B. A., ... & Veenstra, T. D. (2004). High-resolution serum proteomic features for ovarian cancer detection. Endocrine-related cancer, 11(2), 163-178.‏

Bommert, Andrea, et al. "Benchmark for filter methods for feature selection in high-dimensional classification data." Computational Statistics & Data Analysis 143 (2020): 106839. ‏

Abiodun, O. I., Jantan, A., Omolara, A. E., Dada, K. V., Mohamed, N. A., & Arshad, H. (2018). State-of-the-art in artificial neural network applications: A survey. Heliyon, 4(11), e00938.‏

Desai, M., & Shah, M. (2021). An anatomization on breast cancer detection and diagnosis employing multi-layer perceptron neural network (MLP) and Convolutional neural network (CNN). Clinical eHealth, 4, 1-11.‏

Kotsiantis, Sotiris B., Ioannis D. Zaharakis, and Panayiotis E. Pintelas. "Machine learning: a review of classification and combining techniques." Ar-tificial Intelligence Review 26.3 (2006): 159-190.

Munir, K., Elahi, H., Ayub, A., Frezza, F., & Rizzi, A. (2019). Cancer diagnosis using deep learning: a bibliographic review. Cancers, 11(9), 1235.‏

Montgomery, D. C., Runger, G. C., & Hubele, N. F. (2009). Engineering statistics. John Wiley & Sons.‏

Choi, E., & Lee, C. (2003). Feature extraction based on the Bhattacharyya distance. Pattern Recognition, 36(8), 1703-1709. ‏

Seddiki, K., Saudemont, P., Precioso, F., Ogrinc, N., Wisztorski, M., Salz-et, M., ... & Droit, A. (2020). Cumulative learning enables convolutional neural network representations for small mass spectrometry data classifica-tion. Nature communications, 11(1), 5595.

Hato, E. (2021, May). Impact of feature selection for data classification using naive Bayes classifier. In Journal of Physics: Conference Series (Vol. 1879, No. 2, p. 022088). IOP Publishing. ‏

Downloads

Published

2023-09-30

Issue

Section

Computer

How to Cite

Harbi, Z. (2023). Automatic Diagnosis of Ovarian Cancer Based on Relative Entropy and Neural Network. Wasit Journal for Pure Sciences , 2(3), 108-118. https://doi.org/10.31185/wjps.172